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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Kinesin-AMG650
AMG650

Chemical Structure : AMG650

CAS No.: 2410796-79-9

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AMG650 (Sovilnesib, AMG 650)

货号: PC-72904Not For Human Use, Lab Use Only.

AMG650 (Sovilnesib) is an oral, first in class, selective small molecule inhibitor of KIF18A with IC50 of 71 nM.

规格 价格 库存 数量
5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥3980 In stock
50 mg ￥5980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AMG650 (Sovilnesib) is an oral, first in class, selective small molecule inhibitor of KIF18A with IC50 of 71 nM.
KIF18A is a mitotic kinesin motor protein that regulates chromosome positioning during cell division and is overexpressed in a subset of human cancers.

物理化学性质&存储条件

分子量 564.653
分子式 C26H34F2N6O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl)-4-((2-hydroxyethyl)sulfonamido)-2-(6-azaspiro[2.5]octan-6-yl)benzamide

参考文献

1, Patent WO2021211549.

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