AMG 580 |CAS:1227067-71-1 Probechem Biochemicals

Chemical Structure : AMG 580

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AMG 580 (AMG-580;AMG580)

货号: PC-60651Not For Human Use, Lab Use Only.

AMG 580 (AMG580) is a novel potent, selective phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 0.13 nM.

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25 mg		Get quote
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250 mg		Get quote
1 g		Get quote

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生物&药学活性

AMG 580 (AMG580) is a novel potent, selective phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 0.13 nM.
AMG 580 displays no activity against PED isoforms at 30 uM.
AMG 580 is suitable as a tracer for lead optimization to determine target coverage by novel PDE10A inhibitors.
AMG 580 shows potential imaging biomarker for mapping PDE10A distribution and ensuring target coverage by therapeutic PDE10A inhibitors in clinical studies.

物理化学性质&存储条件

分子量	473.508
分子式	C26H24FN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)-2-fluoropropan-1-one

参考文献

1. Chen H, et al. J Pharmacol Exp Ther. 2015 Feb;352(2):327-37.

2. Hu E, et al. ACS Med Chem Lett. 2016 May 19;7(7):719-23.

3. Hwang DR, et al. Nucl Med Biol. 2015 Aug;42(8):654-63.

AMG 580 (AMG-580;AMG580)

生物&药学活性

物理化学性质&存储条件

参考文献

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AMG 580 (AMG-580;AMG580)

生物&药学活性

物理化学性质&存储条件

参考文献

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