AMG333 | TRPM8 antagonist | Probechem Biochemicals

Chemical Structure : AMG333

CAS No.: 1416799-28-4

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AMG333 (AMG-333, AMG 333)

货号: PC-35612Not For Human Use, Lab Use Only.

AMG333 (AMG-333) is a potent, highly selective TRPM8 antagonist with IC50 of 13 nM and 20 nM for hTRPM8 and rTRPM8, respectively.

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25 mg	￥1580	In stock
50 mg	￥2580	In stock
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生物&药学活性

AMG333 (AMG-333) is a potent, highly selective TRPM8 antagonist with IC50 of 13 nM and 20 nM for hTRPM8 and rTRPM8, respectively.
AMG333 displays high selectivity over other TRP channels (IC50>20 uM, TRPV1/V3/V4/A1).
AMG333 exhibits statistically significant and dose-dependent prevention of icilin-induced rat WDS, at 0.6, 1 and 3 mg/kg, inhibits cold-induced increase in blood pressure in the rat CPT in a dose-dependent manner with 1 and 3 mg/kg producing significant inhibition with an ED90 of 1.1 mg/kg, also fully blocks the cold pressor response at 3 mg/kg.

物理化学性质&存储条件

分子量	453.325
分子式	C20H12F5N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-6-(((3-fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic acid

参考文献

1. Horne DB, et al. J Med Chem. 2018 Aug 27. doi: 10.1021/acs.jmedchem.8b00518.

AMG333 (AMG-333, AMG 333)

生物&药学活性

物理化学性质&存储条件

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AMG333 (AMG-333, AMG 333)

生物&药学活性

物理化学性质&存储条件

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