AMG319 |CAS:1608125-21-8 Probechem Biochemicals

Chemical Structure : AMG319

CAS No.: 1608125-21-8

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AMG319 (AMG-319;AMG 319)

货号: PC-43287Not For Human Use, Lab Use Only.

AMG319 (AMG-319) is a potent and selective PI3Kδ inhibitor with biochemical IC50 of 18 nM, displays >80-fold selectivity over PI3Kα/β/γ (IC50=3300/2700/850 nM).

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10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

AMG319 (AMG-319) is a potent and selective PI3Kδ inhibitor with biochemical IC50 of 18 nM, displays >80-fold selectivity over PI3Kα/β/γ (IC50=3300/2700/850 nM).
AMG319 exhibits an IC50 of 16 nM in human whole blood assay (HWB), excellent selectivity over a large panel of protein kinases;.
AMG319 inhibits anti-IgM induced AKT phosphorylation (Ser473) in mouse B cells with IC50 of 1.5 nM, inhibits anti-IgM/CD40L-induced B cell proliferation with IC50 of 8.6 nM.
AMG319 exhibits in vivo efficacy in rodent disease models of inflammation.

物理化学性质&存储条件

分子量	385.397
分子式	C21H16FN7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Quinolinemethanamine, 7-fluoro-α-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-, (αS)-

参考文献

1. Cushing TD, et al. J Med Chem. 2015 Jan 8;58(1):480-511.

AMG319 (AMG-319;AMG 319)

生物&药学活性

物理化学性质&存储条件

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AMG319 (AMG-319;AMG 319)

生物&药学活性

物理化学性质&存储条件

参考文献

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