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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-AMG2504
AMG2504

Chemical Structure : AMG2504

CAS No.: 202342-22-1

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AMG2504 (AMG 2504)

货号: PC-49701Not For Human Use, Lab Use Only.

AMG2504 (AMG 2504) is a selective small molecule TRPA1 inhibitor, inhibits AITC-induced increase in intracellular calcium mediated by TRPA1 in CHO cells with IC50 of 35 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AMG2504 (AMG 2504) is a selective small molecule TRPA1 inhibitor, inhibits AITC-induced increase in intracellular calcium mediated by TRPA1 in CHO cells with IC50 of 35 nM.
    AMG2504 displays no activity against hTRPV1, hTRPM8, hTRPV3 and hTRPV4 at 5 uM.
    AMG2504 marginally inhibited rat TRPA1 activation by AITC.

    物理化学性质&存储条件

    分子量 440.12
    分子式 C15H10Cl4N2O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-nitro-N-(2,2,2-trichloro-1-((4-chlorophenyl)thio)ethyl)benzamide

    参考文献

    1. Lana Klionsky, et al. Mol Pain. 2007 Dec 17;3:39. doi: 10.1186/1744-8069-3-39.

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