AMG-9810 |CAS:545395-94-6 Probechem Biochemicals

Chemical Structure : AMG-9810

CAS No.: 545395-94-6

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AMG-9810 (AMG9810;AMG 9810)

货号: PC-42419Not For Human Use, Lab Use Only.

AMG-9810 is a potent, selective and competitive TRPV1 antagonist with IC50 of 24.5 and 85.6 nM for human and rat TRPV1, respectively.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

AMG-9810 is a potent, selective and competitive TRPV1 antagonist with IC50 of 24.5 and 85.6 nM for human and rat TRPV1, respectively.
AMG-9810 blocks capsaicin-evoked depolarization and CGRP release in cultures of rat dorsal root ganglion primary neurons.
AMG-9810 is the first cinnamide TRPV1 antagonist reported to block capsaicin-induced eye wiping behavior and reverse hyperalgesia in an animal model of inflammatory pain.

物理化学性质&存储条件

分子量	337.42
分子式	C21H23NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	2-Propenamide, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-, (2E)-

参考文献

1. Gavva NR, et al. J Pharmacol Exp Ther. 2005 Apr;313(1):474-84.

2. Gavva NR, et al. J Neurosci. 2007 Mar 28;27(13):3366-74.

3. Peles S, et al. Neuroscience. 2009 Jun 30;161(2):515-25.

AMG-9810 (AMG9810;AMG 9810)

生物&药学活性

物理化学性质&存储条件

参考文献

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AMG-9810 (AMG9810;AMG 9810)

生物&药学活性

物理化学性质&存储条件

参考文献

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