AMG-3969 | GK-GKRP inhibitor | Probechem Biochemicals

Chemical Structure : AMG-3969

CAS No.: 1361224-53-4

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AMG-3969 (AMG3969, AMG 3969)

货号: PC-43024Not For Human Use, Lab Use Only.

AMG-3969 is a potent, metabolically stable Glucokinase (GK)-GKRP (GK regulatory protein) disruptor with IC50 of 4 nM, does not block the GK binding site directly.

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5 mg	￥1880	In stock
10 mg	￥2980	In stock
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100 mg		Get quote

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生物&药学活性

AMG-3969 is a potent, metabolically stable Glucokinase (GK)-GKRP (GK regulatory protein) disruptor with IC50 of 4 nM, does not block the GK binding site directly.
AMG-3969 exhibits robust glucose lowering in diabetic mouse models.
AMG-3969 is highly effective in promoting carbohydrate substrate use, demonstrates a robust pharmacodynamic response (GK translocation, mGKGK translocation EC50=0.2 uM) as well as statistically significant dose-dependent reductions in fed blood glucose levels.

物理化学性质&存储条件

分子量	522.4639
分子式	C21H20F6N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzenemethanol, 4-[(2S)-4-[(6-amino-3-pyridinyl)sulfonyl]-2-(1-propyn-1-yl)-1-piperazinyl]-α,α-bis(trifluoromethyl)-

参考文献

1. Lloyd DJ, et al. Nature. 2013 Dec 19;504(7480):437-40.

2. St Jean DJ Jr, et al. J Med Chem. 2014 Jan 23;57(2):325-38.

3. Nishimura N, et al. J Med Chem. 2014 Apr 10;57(7):3094-116.

AMG-3969 (AMG3969, AMG 3969)

生物&药学活性

物理化学性质&存储条件

参考文献

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AMG-3969 (AMG3969, AMG 3969)

生物&药学活性

物理化学性质&存储条件

参考文献

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