AMG-076 | MCHR1 inhibitor | Probechem Biochemicals

Chemical Structure : AMG-076

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AMG-076 (AMG076, T-71)

货号: PC-61530Not For Human Use, Lab Use Only.

AMG-076 is a potent, selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1) with binding IC50 of 0.6 nM, with dramatically reduced hERG liability (IC50>5 uM).

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生物&药学活性

AMG-076 is a potent, selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1) with binding IC50 of 0.6 nM, with dramatically reduced hERG liability (IC50>5 uM).
AMG-076 shows activity in reducing body weight in in vivo mouse models.
AMG-076 demonstrates good selectivity for MCHR1 and possesses good pharmacokinetic properties across preclinical species.

物理化学性质&存储条件

分子量	462.557
分子式	C26H33F3N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-((4aR,11R,11aS)-11-methyl-9-(trifluoromethyl)-1,3,4,4a,5,6,11,11a-octahydro-2H-pyrido[4,3-b]carbazol-2-yl)ethyl)cyclohexane-1-carboxylic acid

参考文献

1. Mihalic JT, et al. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3781-5.

2. Motani AS, et al. Pharmacol Res Perspect. 2013 Oct;1(1):e00003.

AMG-076 (AMG076, T-71)

生物&药学活性

物理化学性质&存储条件

参考文献

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AMG-076 (AMG076, T-71)

生物&药学活性

物理化学性质&存储条件

参考文献

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