Mavorixafor (AMD-070, AMD-11070) | CXCR4 antagonist | Probechem Biochemicals

Chemical Structure : AMD-070

CAS No.: 558447-26-0

加入收藏

AMD-070 (Mavorixafor, AMD-11070)

货号: PC-45823Not For Human Use, Lab Use Only.

Mavorixafor (AMD-070, AMD-11070) is a potent and selective antagonist of CXCR4 with IC50 of 13 nM in a CXCR4 125I-SDF inhibition binding assay.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3580	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Mavorixafor (AMD-070, AMD-11070) is a potent and selective antagonist of CXCR4 with IC50 of 13 nM in a CXCR4 125I-SDF inhibition binding assay.
AMD-070 displays no significant activity (IC50>10 uM) for a series of other closely GPCRs (CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2).
AMD-070 inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with IC50 of 2 nM and 26 nM, respectively, with noncytotoxic to cells (>23 uM).
AMD-070 exhibits good PK profiles and excellent oral bioavailability.
AMD-070 also inhibits CXCR4/SDF-1-mediated events in ALL cancer cells and transplant models.

物理化学性质&存储条件

分子量	349.4726
分子式	C21H27N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,4-Butanediamine, N1-(1H-benzimidazol-2-ylmethyl)-N1-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-

参考文献

1. Skerlj RT, et al. J Med Chem. 2010 Apr 22;53(8):3376-88.

2. Stone ND, et al. Antimicrob Agents Chemother. 2007 Jul;51(7):2351-8.

3. Parameswaran R, et al. Leukemia. 2011 Aug;25(8):1314-23.

AMD-070 (Mavorixafor, AMD-11070)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

AMD-070 (Mavorixafor, AMD-11070)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.