AM9928 | MAGL covalent inhibitor | Probechem Biochemicals

Chemical Structure : AM9928

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AM9928 (AM-9928)

货号: PC-73012Not For Human Use, Lab Use Only.

AM9928 is a potent, covalent monoacylglycerol lipase (MAGL) inhibitor with IC50 of 8.9 nM (hMAGL).

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生物&药学活性

AM9928 is a potent, covalent monoacylglycerol lipase (MAGL) inhibitor with IC50 of 8.9 nM (hMAGL).
AM9928 covalently binds to and inactivates MAGL by carbamylation of the enzyme's catalytic Ser122 nucleophile.
AM9928 inhibited adhesion and transmigration of breast cancer cells through human brain microvascular endothelial cells (HBMECs), inhibited TNBC's secretion of inflammatory cytokines such as IL-6 and IL-8, and the angiogenic factor VEGF-A.
AM9928 inhibited in vivo changes in BBB permeability and decreased TNBC colonization in brain.
MAGL inhibitor AM9928 is a novel treatment of TNBC tumor growth and TNBC-colonization in the brain.

物理化学性质&存储条件

分子量	396.450
分子式	C24H20N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-cyanopyridin-2-yl 4-(9H-fluoren-9-yl)piperazine-1-carboxylate

参考文献

1. Benchama O, et al. Sci Rep. 2022 Mar 29;12(1):5328.

AM9928 (AM-9928)

生物&药学活性

物理化学性质&存储条件

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AM9928 (AM-9928)

生物&药学活性

物理化学性质&存储条件

参考文献

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