AM432 sodium | CRTH2 inhibitor | Probechem Biochemicals

Chemical Structure : AM432 sodium

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AM432 sodium (AM 432, AM-432)

货号: PC-61577Not For Human Use, Lab Use Only.

AM432 is potent, selective, orally active prostaglandin D2 receptor (DP2/CRTH2) antagonist with binding IC50 of 6 nM for hDP2.

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生物&药学活性

AM432 is potent, selective, orally active prostaglandin D2 receptor (DP2/CRTH2) antagonist with binding IC50 of 6 nM for hDP2.
AM432 shows no cross-reactivity against the TP or IP receptors, COX-1 or COX-2 and minimal activity at DP1 receptor.
AM432 shows excellent potency in a human whole blood eosinophil shape change assay.
AM432 exhibits efficacy in both a murine model of allergic rhinitis and a cigarette smoke induced inflammatory model of COPD.

物理化学性质&存储条件

分子量	511.574
分子式	C29H32N2NaO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4'-(6-ethoxypyridin-3-yl)-2'-((N-ethylcyclopropanecarboxamido)methyl)-6-methoxy-[1,1'-biphenyl]-3-yl)acetic acid, sodium salt

参考文献

1. Stock N, et al. Bioorg Med Chem Lett. 2011 Feb 1;21(3):1036-40.

AM432 sodium (AM 432, AM-432)

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物理化学性质&存储条件

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AM432 sodium (AM 432, AM-432)

生物&药学活性

物理化学性质&存储条件

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