AM4113 | CB1 neutral antagonist | Probechem Biochemicals

Chemical Structure : AM4113

CAS No.: 614726-85-1

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AM4113 (AM-4113)

货号: PC-21521Not For Human Use, Lab Use Only.

AM4113 is a high affinity, selective cannabinoid CB1 neutral antagonist with Ki of 0.89 nM, exhibits 100-fold selectivity over CB2 receptors.

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50 mg	￥2980	In stock
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生物&药学活性

AM4113 is a high affinity, selective cannabinoid CB1 neutral antagonist with Ki of 0.89 nM, exhibits 100-fold selectivity over CB2 receptors.
AM4113 does not change the forskolin-stimulated cAMP accumulation in CB1-transfected HEK cells up to concentrations of 10 µM.
AM4113 attenuated the AM411-induced locomotor suppression (p<0.01 at 2 mg/ kg; p<0.05 at 4 mg/kg) and analgesia.
AM4113 (4.0 mg/kg) alone significantly suppressed locomotor activity compared to vehicle.
AM4113 suppressed food-reinforced operant responding with rats responding on fixed ratio (FR) 1 and 5 schedules of reinforcement in a dose-dependent manner, and also suppressed feeding on high-fat, high-carbohydrate, and lab chow diets.

物理化学性质&存储条件

分子量	380.65
分子式	C17H12Cl3N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

参考文献

1. Sink KS, et al. Neuropsychopharmacology. 2008 Mar;33(4):946-55.

AM4113 (AM-4113)

生物&药学活性

物理化学性质&存储条件

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AM4113 (AM-4113)

生物&药学活性

物理化学性质&存储条件

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