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首页-小分子抑制剂&激动剂-Others-Other Targets-AM404
AM404

Chemical Structure : AM404

CAS No.: 183718-77-6

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AM404 (AM-404)

货号: PC-27605Not For Human Use, Lab Use Only.

AM404 is a seletive inhibitor of anandamide transport with IC50 of 2.2 uM, does not activate cannabinoid receptors or inhibit anandamide hydrolysis.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AM404 is a seletive inhibitor of anandamide transport with IC50 of 2.2 uM, does not activate cannabinoid receptors or inhibit anandamide hydrolysis.
AM404 prevents [3H]anandamide uptake in vitro and enhances various effects of anandamide administration both in vitro and in vivo.
AM404 (10 mg/kg, i.v.) significantly potentiated and prolonged vasodepressor responses to anandamide in anesthesized guinea pigs.

物理化学性质&存储条件

分子量 395.59
分子式 C26H37NO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-hydroxyphenyl)-arachidonamide

参考文献

1. Zygmunt PM, et al. Eur J Pharmacol. 2000 May 12;396(1):39-42.

2. Calignano A, et al. Eur J Pharmacol. 1997 Oct 15;337(1):R1-2.

3. Beltramo M, et al. Science. 1997 Aug 22;277(5329):1094-7.

4. Piomelli D, et al. Proc Natl Acad Sci U S A. 1999 May 11;96(10):5802-7.

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