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首页-小分子抑制剂&激动剂-GPCR-Prostaglandin Receptor-AM211
AM211

Chemical Structure : AM211

CAS No.: 1175526-27-8

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AM211 (AM-211, AM 211)

货号: PC-60673Not For Human Use, Lab Use Only.

AM211 (AM-211) is a potent, selective and orally bioavailable prostaglandin D2 receptor type 2 (DP2) antagonist with IC50 of 4.9 nM for human DP2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AM211 (AM-211) is a potent, selective and orally bioavailable prostaglandin D2 receptor type 2 (DP2) antagonist with IC50 of 4.9 nM for human DP2.
AM211 inhibits radiolabeled PGD2 binding to mouse, guinea pig, and rat DP2 with IC50 values of 7.8, 4.9, and 10.4 nM, respectively, shows no activity for human TP, IP, DP1, and FP.
AM211 potently antagonizes PGD(2)-stimulated functional responses in relevant human cells, and demonstrates efficacy in animal models of allergic inflammation.

物理化学性质&存储条件

分子量 500.518
分子式 C27H27F3N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2'-(3-benzyl-1-ethyl-ureidomethyl)-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl]-acetic acid

参考文献

1. Bain G, et al. J Pharmacol Exp Ther. 2011 Jul;338(1):290-301.

2. Bain G, et al. J Clin Pharmacol. 2012 Oct;52(10):1482-93.

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