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首页-小分子抑制剂&激动剂-GPCR-Cannabinoid Receptor-AM1241
AM1241

Chemical Structure : AM1241

CAS No.: 444912-48-5

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AM1241 (AM-1241;AM 1241)

货号: PC-60729Not For Human Use, Lab Use Only.

AM1241 is a potent, selective cannabinoid receptor CB2 agonist with Ki of 7.1 nM, >80-fold selectivity over CB1 receptors in radioligand binding assay.

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10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2380 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AM1241 is a potent, selective cannabinoid receptor CB2 agonist with Ki of 7.1 nM, >80-fold selectivity over CB1 receptors in radioligand binding assay.
AM1241 suppresses spinal fos protein expression and pain behavior in a rat model of inflammation.
AM1241 dose-dependently reversed tactile and thermal hypersensitivity produced by ligation of the L5 and L6 spinal nerves in rats.

物理化学性质&存储条件

分子量 503.3
分子式 C22H22IN3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2-iodo-5-nitrophenyl)-(1-(1-methylpiperidin-2-ylmethyl)-1H-indol-3-yl)methanone

参考文献

1. Malan TP Jr, et al. Pain. 2001 Sep;93(3):239-45.

2. Nackley AG, et al. Neuroscience. 2003;119(3):747-57.

3. Yao BB, et al. Br J Pharmacol. 2006 Sep;149(2):145-54.

4. Ibrahim MM, et al. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10529-33.

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