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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Glucokinase-AM-9514
AM-9514

Chemical Structure : AM-9514

CAS No.: 1442677-18-0

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AM-9514 (AM 9514, AM9514)

货号: PC-61099Not For Human Use, Lab Use Only.

AM-9514 is a potent glucokinase (GK) activator with EC50 of 0.29 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AM-9514 is a potent glucokinase (GK) activator with EC50 of 0.29 uM.
    AM-9514 exhibits excellent solubility, permeability, in vitro clearances and free fractions in plasma protein binding.
    AM-9514 demonstrates antidiabetic efficacy in vivo with no hypoglycemia.

    物理化学性质&存储条件

    分子量 359.43
    分子式 C18H25N5O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(3-((1-ethyl-1H-pyrazol-5-yl)oxy)-5-(((1r,3s)-3-hydroxy-3-methylcyclobutyl)methyl)pyridin-2-yl)-3-methylurea

    参考文献

    1. Du X, et al. ACS Med Chem Lett. 2014 Nov 22;5(12):1284-9.

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