AM-8719 (AM8719)

Chemical Structure : AM-8719

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货号: PC-27646Not For Human Use, Lab Use Only.

AM-8719 (AM8719) is a potent, selective, CNS-penetrant, orally efficacious KRAS G12C inhibitor with cellular activity (p-ERK, IC50=157 nM).

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100 mg		Get quote

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生物&药学活性

AM-8719 (AM8719) is a potent, selective, CNS-penetrant, orally efficacious KRAS G12C inhibitor with cellular activity (p-ERK, IC50=157 nM).
AM-8719 (30 mg/kg, p.o.) induces robust decrease in p-ERK levels and tumor regression in a KRAS G12C tumor xenograft model (MIA PaCa-2 T2).

物理化学性质&存储条件

分子量	615.70
分子式	C31H40F3N7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-((2R,3R)-1-(6-(4-(2-(3-Methoxyoxetan-3-yl)-4-Methylpyridin-3-yl)Piperidin-1-yl)-2-(Trifluoromethyl)Pyrimidin-4-yl)-2-Methylazetidin-3-yl)Piperazin-1-yl)Prop-2-en-1-one

参考文献

1. Rast S, et al. J Med Chem. 2026 Aug 13;69(15):19050-19064.

AM-8719 (AM8719)

生物&药学活性

物理化学性质&存储条件

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AM-8719 (AM8719)

生物&药学活性

物理化学性质&存储条件

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