AM-8553 |CAS:1352064-70-0 Probechem Biochemicals

Chemical Structure : AM-8553

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AM-8553 (AM8553;AM 8553)

货号: PC-60441Not For Human Use, Lab Use Only.

AM-8553 is a potent, selective, orally bioavailable MDM2-p53 interaction inhibitor with HTRF IC50 of 1.1 nM, SJSA-1 EdU IC50 of 68 nM.

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生物&药学活性

AM-8553 is a potent, selective, orally bioavailable MDM2-p53 interaction inhibitor with HTRF IC50 of 1.1 nM, SJSA-1 EdU IC50 of 68 nM.
AM-8553 exhibits excellent pharmacokinetic properties and in vivo efficacy.

物理化学性质&存储条件

分子量	478.41
分子式	C25H29Cl2NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-3-methyl-2-oxo-3-piperidineacetic acid

参考文献

1. Rew Y, et al. J Med Chem. 2012 Jun 14;55(11):4936-54.

2. Bernard D, et al. J Med Chem. 2012 Jun 14;55(11):4934-5.

3. Lucas BS, et al. J Am Chem Soc. 2012 Aug 1;134(30):12855-60.

AM-8553 (AM8553;AM 8553)

生物&药学活性

物理化学性质&存储条件

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AM-8553 (AM8553;AM 8553)

生物&药学活性

物理化学性质&存储条件

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