AM-6761 |CAS:1584732-36-4 Probechem Biochemicals

Chemical Structure : AM-6761

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AM-6761 (AM 6761;AM6761)

货号: PC-60440Not For Human Use, Lab Use Only.

AM-6761 is a potent MDM2-p53 interaction inhibitor with remarkable biochemical (HTRF IC50=0.1 nM), cellular potency (SJSA-1 EdU IC50=16 nM), and favorable pharmacokinetic properties.

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生物&药学活性

AM-6761 is a potent MDM2-p53 interaction inhibitor with remarkable biochemical (HTRF IC50=0.1 nM), cellular potency (SJSA-1 EdU IC50=16 nM), and favorable pharmacokinetic properties.
AM-6761 shows excellent antitumor activity in the SJSA-1 osteosarcoma xenograft model with ED50 of 11 mg/kg.

物理化学性质&存储条件

分子量	695.686
分子式	C33H37Cl2FN2O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(((3R,5R,6S)-1-((S)-2-(tert-Butylsulfonyl)-1-cyclopropylethyl)- 6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)methyl)thiazol-5-yl)acetic Acid

参考文献

1. Gonzalez AZ, et al. J Med Chem. 2014 Apr 10;57(7):2963-88.

AM-6761 (AM 6761;AM6761)

生物&药学活性

物理化学性质&存储条件

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AM-6761 (AM 6761;AM6761)

生物&药学活性

物理化学性质&存储条件

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