AM-6226 |CAS:1142222-28-3 Probechem Biochemicals

Chemical Structure : AM-6226

加入收藏

AM-6226 (AM 6226;AM6226)

货号: PC-35199Not For Human Use, Lab Use Only.

AM-6226 (AM6226) is a potent, selective, orally bioavailable GPR40 (FFA1) full agonist with EC50 of 0.12 uM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

AM-6226 (AM6226) is a potent, selective, orally bioavailable GPR40 (FFA1) full agonist with EC50 of 0.12 uM.
AM-6226 displays significant glucose lowering during an oral glucose tolerance test (OGTT) at 1 and 10 mg/kg in prediabetic cynomolgus monkeys.

物理化学性质&存储条件

分子量	522.633
分子式	C32H36F2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-(3-((2-((R)-2,2-dimethylcyclopentyl)-2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl)methoxy)-2-fluorophenyl)pentanoic acid

参考文献

1. Sean P. Brown, et al. Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates. ACS Med. Chem. Lett.,DOI: 10.1021/acsmedchemlett.8b00213

2. Luo J, et al. PLoS One. 2012;7(10):e46300.

AM-6226 (AM 6226;AM6226)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

AM-6226 (AM 6226;AM6226)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.