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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Glucokinase-AM-2394
AM-2394

Chemical Structure : AM-2394

CAS No.: 1442684-77-6

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AM-2394 (AM2394)

货号: PC-42091Not For Human Use, Lab Use Only.

AM-2394 (AM2394) is a potent, orally bioavailable Glucokinase (GK) activator with EC50 of 60 nM.

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2 mg (Free Sample) ￥280 In stock
10 mg ￥1180 In stock
25 mg ￥2180 In stock
50 mg ￥3680 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AM-2394 (AM2394) is a potent, orally bioavailable Glucokinase (GK) activator with EC50 of 60 nM.
AM-2394 increases the affinity of GK for glucose by 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models.
AM-2394 lowers glucose excursion in an ob/ob mouse model of diabetes.

物理化学性质&存储条件

分子量 423.465
分子式 C22H25N5O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 30 mg/mL
Chemical Name/SMILES

Urea, N-[6'-(2-hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methyl-

参考文献

1. Kohn TJ, et al. ACS Med Chem Lett. 2016 Jun 1;7(7):666-70.

2. Dransfield PJ, et al. ACS Med Chem Lett. 2016 May 23;7(7):714-8.

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