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首页-小分子抑制剂&激动剂-GPCR-Free Fatty Acid Receptor (FFAR)-AM-1638
AM-1638

Chemical Structure : AM-1638

CAS No.: 1142214-62-7

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AM-1638 (AM1638;AM 1638;AMG-1638)

货号: PC-60257Not For Human Use, Lab Use Only.

AM-1638 is a potent, orally bioavailable, full agonist of GPR40/FFA1 with EC50 of 0.16 uM.

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5 mg ￥2880 In stock
10 mg ￥4580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AM-1638 is a potent, orally bioavailable, full agonist of GPR40/FFA1 with EC50 of 0.16 uM.
AM-1638 stimulates GLP-1 and GIP secretion from intestinal enteroendocrine cells and increase GSIS from pancreatic islets.
AM-1638 enhances glucose control in mouse models of type 2 diabetes.

物理化学性质&存储条件

分子量 514.637
分子式 C33H35FO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-3-cyclopropyl-3-(3-((2-(5,5-dimethylcyclopent-1-en-1-yl)-2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl)methoxy)phenyl)propanoic acid

参考文献

1. Brown SP, et al. ACS Med Chem Lett. 2012 Aug 15;3(9):726-30.

2. Luo J, et al. PLoS One. 2012;7(10):e46300.

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