AM-0902 |CAS:1883711-97-4 Probechem Biochemicals

Chemical Structure : AM-0902

CAS No.: 1883711-97-4

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AM-0902 (AMG0902;AM0902)

货号: PC-61124Not For Human Use, Lab Use Only.

AM-0902 (AMG0902) is a potent, selective, orally active TRPA1 channel antagonist with IC50 of 71 and 131 nM for rTRPA1 and hTRPA1 in Ca2+ flux assays respectively, without agonist activity (EC50>40 uM).

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3680	In stock
100 mg		Get quote

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生物&药学活性

AM-0902 (AMG0902) is a potent, selective, orally active TRPA1 channel antagonist with IC50 of 71 and 131 nM for rTRPA1 and hTRPA1 in Ca2+ flux assays respectively, without agonist activity (EC50>40 uM).
AM-0902 (AMG0902) shows good selectivity over other TRP channels, including human TRPV1 and TRPV4, rat TRPV1, TRPV3, and TRPM8 (IC50>10 uM).
AM-0902 (AMG0902) demonstrates dose-dependent inhibition of AITC-induced flinching in rats.

物理化学性质&存储条件

分子量	370.797
分子式	C17H15ClN6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((3-(4-Chlorophenethyl)-1,2,4-oxadiazol-5-yl)methyl)-7-methyl-1H-purin-6(7H)-one

参考文献

1. Schenkel LB, et al. J Med Chem. 2016 Mar 24;59(6):2794-809.

AM-0902 (AMG0902;AM0902)

生物&药学活性

物理化学性质&存储条件

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AM-0902 (AMG0902;AM0902)

生物&药学活性

物理化学性质&存储条件

参考文献

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