AM-001 | EPAC1 inhibitor | Probechem Biochemicals

Chemical Structure : AM-001

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AM-001 (AM001)

货号: PC-23228Not For Human Use, Lab Use Only.

AM-001 is a potent, selective and allosteric inhibitor of exchange proteins directly activated by cAMP 1 (EPAC1), inhibits Sp-8-CPT-induced Epac1 (EC50=47.8 uM) but not Epac2 activity.

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生物&药学活性

AM-001 is a potent, selective and allosteric inhibitor of exchange proteins directly activated by cAMP 1 (EPAC1), inhibits Sp-8-CPT-induced Epac1 (EC50=47.8 uM) but not Epac2 activity.
AM-001 shows .no antagonist effect on Epac2 or protein kinase A activity.
AM-001 prevents the activation of the Epac1 downstream effector Rap1 in cultured cells, in response to the Epac1 preferential agonist, 8-CPT-AM.
AM-001 reduces infarct size after mouse myocardial ischaemia/reperfusion injury. attenuates cardiac hypertrophy, inflammation and fibrosis, and improves cardiac function during chronic β-adrenergic receptor activation with isoprenaline (ISO) in mice.

物理化学性质&存储条件

分子量	445.53
分子式	C24H16FN3OS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-amino-N-(4-fluorophenyl)-4-phenyl-6-(thiophen-2-yl)thieno[2,3-b]pyridine-2-carboxamide

参考文献

1. Bufano M, et al. J Comput Aided Mol Des. 2020 Nov;34(11):1171-1179.

2. Laudette M, et al. Cardiovasc Res. 2019 Oct 1;115(12):1766-1777.

AM-001 (AM001)

生物&药学活性

物理化学性质&存储条件

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AM-001 (AM001)

生物&药学活性

物理化学性质&存储条件

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