ALW-II-49-7 | DDR2 inhibitor | Probechem Biochemicals

Chemical Structure : ALW-II-49-7

CAS No.: 1135219-23-6

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ALW-II-49-7 (DDR2-IN-1)

货号: PC-62396Not For Human Use, Lab Use Only.

ALW-II-49-7 (DDR2-IN-1) is a potent, selective DDR2 inhibitor with IC50 of 18.6 nM, also shows ability to inhibit DDR1 and Ephrin-family kinases (IC50=40 nM for EphB2).

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4780	In stock
50 mg	￥7580	In stock
100 mg		Get quote

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生物&药学活性

ALW-II-49-7 (DDR2-IN-1) is a potent, selective DDR2 inhibitor with IC50 of 18.6 nM, also shows ability to inhibit DDR1 and Ephrin-family kinases (IC50=40 nM for EphB2).
ALW-II-49-7 displays excellent overall kinase selectivity against a panel of over 350 kinases.
ALW-II-49-7 decreases DDR2 phosphorylation but has little effect on the proliferation of DDR2 mutated cancer cell lines.

物理化学性质&存储条件

分子量	414.388
分子式	C21H17F3N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)amino)nicotinamide

参考文献

1. Terai H, et al. ACS Chem Biol. 2015 Dec 18;10(12):2687-96.

2. Choi Y, et al. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70.

ALW-II-49-7 (DDR2-IN-1)

生物&药学活性

物理化学性质&存储条件

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ALW-II-49-7 (DDR2-IN-1)

生物&药学活性

物理化学性质&存储条件

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