ALW-II-41-27 | EPHA2 inhibitor | Probechem Biochemicals

Chemical Structure : ALW-II-41-27

CAS No.: 1186206-79-0

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ALW-II-41-27 (EPHA2 inhibitor)

货号: PC-45397Not For Human Use, Lab Use Only.

ALW-II-41-27 is an ATP-competitive EPHA2 RTK inhibitor with IC50 of 11 nM.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2380	In stock
25 mg	￥3980	In stock
50 mg	￥5880	In stock
100 mg		Get quote

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生物&药学活性

ALW-II-41-27 is an ATP-competitive EPHA2 RTK inhibitor with IC50 of 11 nM.
ALW-II-41-27 reduces the number of viable NSCLC cells in a time-dependent and dose-dependent manner in vitro and induces tumor regression in human NSCLC xenografts in vivo.
ALW-II-41-27 decreases both survival and proliferation of erlotinib-resistant tumor cells and inhibits tumor growth in vivo.
ALW-II-41-27 also decreasrd viability of cells with acquired resistance to the third-generation EGFR TKI AZD9291.

物理化学性质&存储条件

分子量	607.689
分子式	C32H32F3N5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 47 mg/mL
Chemical Name/SMILES	Benzamide, N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[[[5-(2-thienyl)-3-pyridinyl]carbonyl]amino]-

参考文献

1. Choi Y, et al. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70.

2. Amato KR, et al. J Clin Invest. 2014 May;124(5):2037-49.

3. Amato KR, et al. Cancer Res. 2016 Jan 15;76(2):305-18.

ALW-II-41-27 (EPHA2 inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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ALW-II-41-27 (EPHA2 inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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