ALT-007 | Serine palmitoyltransferase inhibitor | Probechem Biochemicals

Chemical Structure : ALT-007

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ALT-007 (ALT007)

货号: PC-23850Not For Human Use, Lab Use Only.

ALT-007 is a potent, selective and orally bioavailable inhibitor of serine palmitoyltransferase (SPT) with enzyme IC50 of 0.54 nM.

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生物&药学活性

ALT-007 is a potent, selective and orally bioavailable inhibitor of serine palmitoyltransferase (SPT) with enzyme IC50 of 0.54 nM.
ALT-007 potently inhibited both SPT enzyme (IC50 =1.2 nM) and HCC4006 cell growth (IP = 3.9 nM).
ALT-007 displayed potent growth inhibitory activity against both HCC4006 and PL-21 cells on the same level with Myriocin.
ALT-007 is an orally bioavailable SPT inhibitor with in vivo antitumor efficacy, which provides a useful tool for assessing the pharmaceutical potential of SPT inhibitors especially against cancer.

物理化学性质&存储条件

分子量	533.51
分子式	C25H26F3N5O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(4-(5,6-dimethoxynicotinoyl)-1-isopropyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-b]pyridin-7-yl)-2-(trifluoromethoxy)benzamide

参考文献

1. Poisson J, et al. ACS Pharmacol Transl Sci. 2024 Dec 29;8(1):203-215.

2. Kojima T, et al. Bioorg Med Chem. 2018 May 15;26(9):2452-2465.

ALT-007 (ALT007)

生物&药学活性

物理化学性质&存储条件

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ALT-007 (ALT007)

生物&药学活性

物理化学性质&存储条件

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