ALS-8176 (Lumicitabine) | RSV polymerase inhibitor | Probechem Biochemicals

Chemical Structure : ALS-8176

CAS No.: 1445385-02-3

加入收藏

ALS-8176 (Lumicitabine, ALS8176)

货号: PC-43307Not For Human Use, Lab Use Only.

ALS-8176 (Lumicitabine) is the 3',5'-di-O-isobutyryl prodrug of ALS-8112 5'-triphosphate (ALS-8112-TP), which is a potent, selective RSV polymerase inhibitor with IC50 of 20 nM.

规格	价格	库存
5 mg	￥2880	In stock
10 mg	￥4780	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

ALS-8176 (Lumicitabine) is the 3',5'-di-O-isobutyryl prodrug of ALS-8112 5'-triphosphate (ALS-8112-TP), which is a potent, selective RSV polymerase inhibitor with IC50 of 20 nM.
ALS-8176 demonstrates good oral bioavailability and a high level of ALS-8112-TP in vivo, exhibits excellent anti-RSV efficacy and safety in vivo and clinical trials.

物理化学性质&存储条件

分子量	433.859
分子式	C18H25ClFN3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cytidine, 4'-C-(chloromethyl)-2'-deoxy-2'-fluoro-, 3',5'-bis(2-methylpropanoate)

参考文献

1. Deval J, et al. PLoS Pathog. 2015 Jun 22;11(6):e1004995.

2. Wang G, et al. J Med Chem. 2015 Feb 26;58(4):1862-78.

3. Jordan PC, et al. ACS Chem Biol. 2017 Jan 20;12(1):83-91.

ALS-8176 (Lumicitabine, ALS8176)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

ALS-8176 (Lumicitabine, ALS8176)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.