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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-RSV-ALS-8112
ALS-8112

Chemical Structure : ALS-8112

CAS No.: 1445379-92-9

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ALS-8112 (ALS 8112;ALS8112)

货号: PC-43306Not For Human Use, Lab Use Only.

ALS-8112 is a potent, selective RSV polymerase inhibitor, the 5'-triphosphate of ALS-8112 (ALS-8112-TP) inhibits RSV polymerase (IC50=20 nM) without appreciable inhibition of human DNA and RNA polymerases.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ALS-8112 is a potent, selective RSV polymerase inhibitor, the 5'-triphosphate of ALS-8112 (ALS-8112-TP) inhibits RSV polymerase (IC50=20 nM) without appreciable inhibition of human DNA and RNA polymerases.
ALS-8112 is the active form of ALS-8176, inhibits all strains of RSV in vitro and is specific for paramyxoviruses and rhabdoviruses.

物理化学性质&存储条件

分子量 293.6793
分子式 C10H13ClFN3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 47 mg/mL
Chemical Name/SMILES

Cytidine, 4'-C-(chloromethyl)-2'-deoxy-2'-fluoro-

参考文献

1. Deval J, et al. PLoS Pathog. 2015 Jun 22;11(6):e1004995.

2. Wang G, et al. J Med Chem. 2015 Feb 26;58(4):1862-78.

3. Jordan PC, et al. ACS Chem Biol. 2017 Jan 20;12(1):83-91.

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