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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-Akt-ALM301
ALM301

Chemical Structure : ALM301

CAS No.: 1313439-71-2

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ALM301 (ALM-301)

货号: PC-49355Not For Human Use, Lab Use Only.

ALM301 is a potent, selective and allosteric inhibitor of AKT1 and AKT2 with IC50 of 125 nM and 95 nM respectively.

规格 价格 库存 数量
5 mg ￥3580 In stock
10 mg ￥5580 In stock
25 mg ￥8580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ALM301 (ALM-301) is a potent, selective and allosteric inhibitor of AKT1 and AKT2 with IC50 of 125 nM and 95 nM respectively.
ALM301 demonstrates excellent selectivity against 450 kinases at 10 uM.
ALM301 inhibits proliferation in a cancer cell line panel. MCF-7 cells, containing a PI3KCA mutation, is among the most sensitive with IC50 of 2.25 uM.
ALM301 inhibits AKT phosphorylation and modulates downstream signalling in vitro.
ALM301 orally dosed at 10, 30 and 100 mg/kg q.d. or q.o.d. showed significant anti-tumour efficacy in an A549 lung cancer xenograft.

物理化学性质&存储条件

分子量 415.49
分子式 C25H25N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-[4-(cis-1-Amino-3-hydroxycyclobutyl)phenyl]-1-ethyl-7-phenyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one

参考文献

1. Natalie Page, et al. Scientific Reports volume 12, Article number: 15715 (2022)

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