ALLO-1 |CAS:37468-32-9 Probechem Biochemicals

Chemical Structure : ALLO-1

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ALLO-1 (ALLO1)

货号: PC-62177Not For Human Use, Lab Use Only.

ALLO1 is a potent Smoothened (Smo) antagonist that inhibits both wild-type (IC50=50 nM) and mutant Smo, including the D473H Smo mutant (IC50s = 300-1000 nM).

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生物&药学活性

ALLO1 is a potent Smoothened (Smo) antagonist that inhibits both wild-type (IC50=50 nM) and mutant Smo, including the D473H Smo mutant (IC50s = 300-1000 nM); binds to the SMO cysteine-rich domain, which is a different mechanism of interaction compared to other known SMO ligands that bind the transmembrane pocket.

物理化学性质&存储条件

分子量	314.769
分子式	C17H15ClN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-chlorophenyl)-5-methyl-1-(phenylmethyl)-2,4-imidazolidinedione

参考文献

1. Tao H, et al. Chem Biol. 2011 Apr 22;18(4):432-7.

2. Sharpe HJ, et al. Nat Chem Biol. 2015 Apr;11(4):246-55.

ALLO-1 (ALLO1)

生物&药学活性

物理化学性质&存储条件

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ALLO-1 (ALLO1)

生物&药学活性

物理化学性质&存储条件

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