ALLM |Cas:136632-32-1 Buy ALLM from ProbeChem, Global Biochemicals Supplier

Chemical Structure : ALLM

CAS No.: 136632-32-1

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ALLM (Ac-Leu-Leu-Met-CHO)

货号: PC-70124Not For Human Use, Lab Use Only.

ALLM (Ac-Leu-Leu-Met-CHO) is a potent, cell-permeable calpain inhibitor with Ki of 0.6 and 100 nM for calpain L and calpain B, respectively.

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生物&药学活性

ALLM (Ac-Leu-Leu-Met-CHO) is a potent, cell-permeable calpain inhibitor with Ki of 0.6 and 100 nM for calpain L and calpain B, respectively.
ALLM inhibits the activities of Ca(2+)-dependent neutral proteases as well as lysosomal proteases, including cathepsin L, cathepsin B, and cathepsin D.
ALLM induces apoptosis in rat pituitary tumor cells by specific caspase activation.

物理化学性质&存储条件

分子量	401.57
分子式	C19H35N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-Acetyl-L-leucyl-L-leucyl-L-methional

参考文献

1. Neumann D, et al. Biochem J. 1996 Jan 15;313 ( Pt 2):391-9.

2. Inoue S, et al. J Biol Chem. 1991 Jul 15;266(20):13311-7.

3. Yu R, et al. J Endocrinol. 2002 Sep;174(3):379-86.

ALLM (Ac-Leu-Leu-Met-CHO)

生物&药学活性

物理化学性质&存储条件

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ALLM (Ac-Leu-Leu-Met-CHO)

生物&药学活性

物理化学性质&存储条件

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