ALKBH5 inhibitor 18l

Chemical Structure : ALKBH5 inhibitor 18l

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货号: PC-24023Not For Human Use, Lab Use Only.

ALKBH5 inhibitor 18l is a potent, selective, covalent inhibitor of N6-methyladenosine (m6A) demethylase ALKBH5 with Kd of 804 nM, IC50 of 0.62 uM.

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250 mg		Get quote

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生物&药学活性

ALKBH5 inhibitor 18l is a potent, selective, covalent inhibitor of N6-methyladenosine (m6A) demethylase ALKBH5 with Kd of 804 nM, IC50 of 0.62 uM.
ALKBH5 inhibitor 18l is a highly selective inhibitor of ALKBH5 rather than FTO.
ALKBH5 inhibitor 18l exerts potent antiproliferative effect on NB4 cells with IC50 of 0.63 μM.
ALKBH5 inhibitor 18l directly targeted ALKBH5 in cells and altered m6A levels on mRNA, blocked the related downstream signal pathways, promoted differentiation, and induced apoptosis.

物理化学性质&存储条件

分子量	231.25
分子式	C13H13NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-methoxyphenethyl)-1H-pyrrole-2,5-dione

参考文献

1. Wu H, et al. Angew Chem Int Ed Engl. 2025 Feb 20:e202424928.