ALK2 R206H inhibitor 23

首页-小分子抑制剂&激动剂-Tyrosine Kinase-Anaplastic Lymphoma Kinase (ALK)-ALK2 R206H inhibitor 23

Chemical Structure : ALK2 R206H inhibitor 23

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货号: PC-72134Not For Human Use, Lab Use Only.

ALK2 R206H inhibitor 23 is a potent and selective inhibitor of Activin Receptor-Like Kinase-2 (ALK2/ACVR1) with IC50 of 8 nM for mutant ALK2 R206H.

规格	价格	库存	数量
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100 mg		Get quote
250 mg		Get quote

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ALK2 R206H inhibitor 23 is a potent and selective inhibitor of Activin Receptor-Like Kinase-2 (ALK2/ACVR1) with IC50 of 8 nM for mutant ALK2 R206H.
ALK2 R206H inhibitor 23 displays >15-fold selectivity over ALK1/ALK3, and >100-fold over ALK5/ALK6.

物理化学性质&存储条件

分子量	555.12
分子式	C29H39ClN6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-amino-6-(2-chloro-4-((4-morpholinopiperidin-1-yl)methyl)phenyl)-N-(4-hydroxybicyclo[2.2.2]octan-1-yl)pyrazine-2-carboxamide

参考文献

1. Thomas Ullrich, et al. Bioorg Med Chem Lett. 2022 May 15:64:128667.

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