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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Thyroid Hormone Receptor (THR)-ALG-055009
ALG-055009

Chemical Structure : ALG-055009

CAS No.: 2542029-03-6

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ALG-055009 (ALG055009)

货号: PC-22997Not For Human Use, Lab Use Only.

ALG-055009 is a potent, selective thyroid hormone receptor β (THR-β) agonist with EC50 of 63 nM, 5.7 fold selective over THR-α.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ALG-055009 is a potent, selective thyroid hormone receptor β (THR-β) agonist with EC50 of 63 nM, 5.7 fold selective over THR-α.
ALG-055009 (>0.075 mg/kg) reduces serum lipid levels in a high fat diet rat model, significantly increases hepatic Dio1 and Me1 gene expression at doses of 0.15 and 0.5 mg/kg.

物理化学性质&存储条件

分子量 425.23
分子式 C16H14Cl2N6O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-Amino-2-[3,5-dichloro-4-[(5-isopropyl-6-oxo-1H-pyridazin-3-yl)oxy]phenyl]-4H-1,2,4-triazine-3,5-dione

参考文献

1. Vandyck K, et al. J Med Chem. 2024 Sep 2. doi: 10.1021/acs.jmedchem.4c01029.

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