ALDH3A1 inhibitor EN40 |CAS:2094547-67-6 Probechem Biochemicals

Chemical Structure : ALDH3A1 inhibitor EN40

CAS No.: 2094547-67-6

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ALDH3A1 inhibitor EN40 (EN40)

货号: PC-35380Not For Human Use, Lab Use Only.

ALDH3A1 inhibitor EN40 is a potent and selective, covalent, in vivo-active inhibitor of ALDH3A1 with IC50 of 2 uM, demonstrates no activity against ALDH1A3 and ALDH6A1 at 30 uM.

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生物&药学活性

ALDH3A1 inhibitor EN40 is a potent and selective, covalent, in vivo-active inhibitor of ALDH3A1 with IC50 of 2 uM, demonstrates no activity against ALDH1A3 and ALDH6A1 at 30 uM.
ALDH3A1 inhibitor EN40 also does not show any observable competition against lysine-reactive probe labeling of A549 proteomes.
ALDH3A1 inhibitor EN40 specifically inhibits the lung cancer cell lines expressing ALDH3A1, but not in the cell lines that do not express ALDH3A1.
ALDH3A1 inhibitor EN40 inhibits ALDH3A1 activity and impairs lung cancer pathogenicity in vivo.

物理化学性质&存储条件

分子量	217.268
分子式	C13H15NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(5-(furan-2-yl)-4-methyl-3,6-dihydropyridin-1(2H)-yl)prop-2-en-1-one

参考文献

1. Counihan JL, et al. ACS Chem Biol. 2018 Jul 13. doi: 10.1021/acschembio.8b00381.

ALDH3A1 inhibitor EN40 (EN40)

生物&药学活性

物理化学性质&存储条件

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ALDH3A1 inhibitor EN40 (EN40)

生物&药学活性

物理化学性质&存储条件

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