ALDH1A inhibitor 673A |CAS:109437-62-9 Probechem Biochemicals

Chemical Structure : ALDH1A inhibitor 673A

CAS No.: 109437-62-9

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ALDH1A inhibitor 673A (ALDH1Ai 673A)

货号: PC-36129Not For Human Use, Lab Use Only.

ALDH1A inhibitor 673A (ALDH1Ai 673A) is a potent, selective, pan-ALDH1A inhibitor with IC50 of 246, 230 and 348 nM for ALDH1A1, ALDH1A2 and ALDH1A3, respectively.

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10 mg	￥4580	In stock
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生物&药学活性

ALDH1A inhibitor 673A (ALDH1Ai 673A) is a potent, selective, pan-ALDH1A inhibitor with IC50 of 246, 230 and 348 nM for ALDH1A1, ALDH1A2 and ALDH1A3, respectively.
ALDH1Ai 673A shows no significant activity against ALDH2 (IC50 14 mM) or numerous other ALDH family members.
ALDH1Ai 673A preferentially kills CD133+ ovarian cancer stem-like cells (CSCs), induces necroptotic CSC death, mediated, in part, by the induction of mitochondrial uncoupling proteins (UCPs) and reduction in oxidative phosphorylation.
ALDH1Ai 673A is highly synergistic with chemotherapy, reducing tumor initiation capacity and increasing tumor eradication in vivo.

物理化学性质&存储条件

分子量	223.275
分子式	C15H13NO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(isoindolin-2-yl)benzaldehyde

参考文献

1. Chefetz I, et al. Cell Rep. 2019 Mar 12;26(11):3061-3075.e6.

ALDH1A inhibitor 673A (ALDH1Ai 673A)

生物&药学活性

物理化学性质&存储条件

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ALDH1A inhibitor 673A (ALDH1Ai 673A)

生物&药学活性

物理化学性质&存储条件

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