ALDH1A1 inhibitor CM37 (CM037)

Chemical Structure : ALDH1A1 inhibitor CM37

CAS No.: 896795-60-1

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货号: PC-49239Not For Human Use, Lab Use Only.

ALDH1A1 inhibitor CM37 is a selective and competitive inhibitor of ALDH1A1 with Ki of 300 nM, shows minimal inhibitory effects for ALDH1A2, ALDH1A3, ALDH2, or ALDH3A1 at 20 uM.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

ALDH1A1 inhibitor CM37 is a selective and competitive inhibitor of ALDH1A1 with Ki of 300 nM, shows minimal inhibitory effects for ALDH1A2, ALDH1A3, ALDH2, or ALDH3A1 at 20 uM.
CM37 reduced ovarian cancer cell proliferation as spheroids under low attachment growth conditions and the expression of stemness-associated markers (OCT4 and SOX2) in ALDH+ cells fluorescence-activated cell sorting (FACS)-sorted from cell lines and malignant OC ascites.
CM37 promoted DNA damage in OC cells, as evidenced by induction of γH2AX.
CM37 augmented intracellular ROS accumulation, which in turn led to increased DNA damage and reduced OC cell viability.

物理化学性质&存储条件

分子量	431.569
分子式	C21H25N3O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 2-((4-oxo-3-(3-(pyrrolidin-1-yl)propyl)-3,4-dihydrobenzo[4,5]thieno[3,2-d]pyrimidin-2-yl)thio)acetate

参考文献

1. Condello S., et al. Oncogene. 2015;34:2297–2308.

2. Nkechiyere G Nwani, et al. Cancers (Basel). 2019 Apr 8;11(4):502.