AL906 | EGFR inhibitor | Probechem Biochemicals

Chemical Structure : AL906

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AL906 (AL 906, AL-906)

货号: PC-72058Not For Human Use, Lab Use Only.

AL906 (AL 906) is a novel potent, selective EGFR inhibitor with IC50 of 12 nM (EGFR phosphorylation).

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生物&药学活性

AL906 (AL 906) is a novel potent, selective EGFR inhibitor with IC50 of 12 nM (EGFR phosphorylation).
AL906 blocked EGF-induced EGFR phosphorylation at doses as low as 1 uM in EGF-stimulated OV90 and DU145 cells.
AL906 growth inhibitory activity was superior to that of the clinical drug gefitinib.
AL906 selectively inhibited the growth of the NIH3T3-EGFR and HER2 transfectants in isogenic NIH3T3 transfected cell panel.

物理化学性质&存储条件

分子量	695.137
分子式	C34H31ClN10O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 Month
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((3-chlorophenyl)amino)quinazolin-6-yl)-4-((methyl(2-(3-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)propanamido)ethyl)amino)methyl)benzamide

参考文献

1. Nahid Golabi, et al. Invest New Drugs. 2021 Feb;39(1):240-250.

AL906 (AL 906, AL-906)

生物&药学活性

物理化学性质&存储条件

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AL906 (AL 906, AL-906)

生物&药学活性

物理化学性质&存储条件

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