AL398 | NSUN6 inhibitor | Probechem Biochemicals

Chemical Structure : AL398

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AL398 (AL-398)

货号: PC-27909Not For Human Use, Lab Use Only.

AL398 is a specific small molecule inhibitor of m5C methyltransferase NSUN6 with IC50 of 2.796 uM, shows negligible effects on the stability of other methyltransferases, including NOP2, NSUN2, and METTL3.

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生物&药学活性

AL398 is a specific small molecule inhibitor of m5C methyltransferase NSUN6 with IC50 of 2.796 uM, shows negligible effects on the stability of other methyltransferases, including NOP2, NSUN2, and METTL3.
AL398 attenuates metastatic potential of endometrial cancer cells in vitro.
Snail expression effectively counteracts AL398's inhibitory phenotype.
AL398 (8 mg/kg and 12 mg/kg) induces significant, dose-dependent suppression of tumor growth inmouse xenograft model.
AL398 inhibits endometrial cancer metastasis in vivo by targeting the NSUN6/m5C/Snail pathway.

物理化学性质&存储条件

分子量	266.26
分子式	C11H14N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,4S,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

参考文献

1. Zhao X, et al. Adv Sci (Weinh). 2026 Aug 28:e77359.

AL398 (AL-398)

生物&药学活性

物理化学性质&存储条件

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AL398 (AL-398)

生物&药学活性

物理化学性质&存储条件

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