AL-GDa62

Chemical Structure : AL-GDa62

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货号: PC-72537Not For Human Use, Lab Use Only.

AL-GDa62 is a specific inhibitor of TCOF1, ARPC5, and UBC9, inhibits SUMOylation at low micromolar concentrations.

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生物&药学活性

AL-GDa62 is a specific inhibitor of TCOF1, ARPC5, and UBC9, inhibits SUMOylation at low micromolar concentrations.
AL-GDa62 preferentially induced apoptosis in CDH1–/– cells, and Cdh1–/– mammary and gastric organoids were significantly more sensitive to AL-GDa62 at low micromolar concentrations.
AL-GDa62 is a potential synthetic lethal lead for the treatment of gastric cancer.

物理化学性质&存储条件

分子量	393.506
分子式	C24H28FN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-fluorobenzyl)-2-methyl-6-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-amine

参考文献

1. Luxenburger A, et al. J Med Chem. 2021 Dec 23;64(24):18114-18142.

AL-GDa62

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AL-GDa62

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