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首页-小分子抑制剂&激动剂-GPCR-5-HT Receptor-AL-34662
AL-34662

Chemical Structure : AL-34662

CAS No.: 210580-75-9

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AL-34662 (AL34662)

货号: PC-27112Not For Human Use, Lab Use Only.

AL-34662 is a potent, selective, and efficacious serotonin-2 (5-HT2) receptor agonist with binding IC50 of 0.8-1.5 nM for rat and human 5-HT2 receptors, and 3-14.5 nM for cloned human 5-HT2A-C receptors.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AL-34662 is a potent, selective, and efficacious serotonin-2 (5-HT2) receptor agonist with binding IC50 of 0.8-1.5 nM for rat and human 5-HT2 receptors, and 3-14.5 nM for cloned human 5-HT2A-C receptors.
AL-34662 stimulated phosphoinositide turnover in human ciliary muscle (h-CM; EC50=289+/-80 nM) and in human trabecular meshwork (h-TM; EC50=254+/-50 nM) cells.
AL-34662 also mobilized intracellular Ca2+ ([Ca2+]i) in h-CM (EC50=140+/-23 nM) and h-TM (EC50=38+/-8 nM) cells.
AL-34662 caused relatively minimal ocular discomfort and hyperemia in rabbit and guinea pig eyes, efficaciously lowered intraocular pressure (IOP) in the conscious ocular hypertensive monkey eyes.

物理化学性质&存储条件

分子量 191.23
分子式 C10H13N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-1-(2-Aminopropyl)-1H-indazol-6-ol

参考文献

1. Sharif NA, et al. J Ocul Pharmacol Ther. 2007 Feb;23(1):1-13.

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