AKT1 (E17K) inhibitor compound 3

Chemical Structure : AKT1 (E17K) inhibitor compound 3

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货号: PC-23915Not For Human Use, Lab Use Only.

AKT1 (E17K) inhibitor compound 3 is a potent, mutant-selective inhibitor of AKT1 (E17K) mutant, potently reduces cell viability of LAPC4-CR cells with EC50 of 20 nM.

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生物&药学活性

AKT1 (E17K) inhibitor compound 3 is a potent, mutant-selective inhibitor of AKT1 (E17K) mutant, potently reduces cell viability of LAPC4-CR cells with EC50 of 20 nM.
compound 3 preferentially forms a reversible imine conjugate with Lys17 in AKT1 (E17K).
Compound 3 shows selectivity for AKT1 (E17K) over AKT2 in terms of both residence time and thermal stabilization.
Compound 3 potently inhibited AKT signalling in E17K-mutant HBCx-2 breast cancer cells.

物理化学性质&存储条件

分子量	540.63
分子式	C33H28N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-((4-(2-(2-aminopyridin-3-yl)-5-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)benzyl)amino)ethyl)-2-hydroxybenzaldehyde

参考文献

1. Craven GB, et al. Nature. 2025 Jan;637(8044):205-214.