AKR1C3 inhibitor SG-55 | AKR1C3 inhibitor | Probechem Biochemicals

Chemical Structure : AKR1C3 inhibitor SG-55

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AKR1C3 inhibitor SG-55 (SG55)

货号: PC-26001Not For Human Use, Lab Use Only.

AKR1C3 inhibitor SG-55 is a potent, selective and noncompetitive aldo-keto reductase 1C3 (AKR1C3) inhibitor with IC50 of 5 nM, with no inhibition against AKR1C1, AKR1C2, and AKR1C4.

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生物&药学活性

AKR1C3 inhibitor SG-55 is a potent, selective and noncompetitive aldo-keto reductase 1C3 (AKR1C3) inhibitor with IC50 of 5 nM, with no inhibition against AKR1C1, AKR1C2, and AKR1C4.
SG-55 elevated the reduced/oxidized nicotinamide adenine dinucleotide phosphate (NADPH/NADP+) ratio, decreased the reduced/oxidized glutathione (GSH/GSSG) ratio, induced DNA double-strand breaks.
SG-55 synergized with Osimertinib to suppress proliferation, clonogenicity, and survival in 19Del/T790M/C797S mutant NSCLC cells.
SG-55 demonstrated efficacy in xenograft models and exhibited favorable pharmacokinetics in mice.

物理化学性质&存储条件

分子量	319.36
分子式	C19H17N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(cyclopropanecarbonyl)-1H-pyrrole-2-carbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonitrile

参考文献

1. Can Guo, et al. J Med Chem. 2026 Jan 29. doi: 10.1021/acs.jmedchem.5c03655.

AKR1C3 inhibitor SG-55 (SG55)

生物&药学活性

物理化学性质&存储条件

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AKR1C3 inhibitor SG-55 (SG55)

生物&药学活性

物理化学性质&存储条件

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