欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Others-Other Targets-AKBA
AKBA

Chemical Structure : AKBA

CAS No.: 67416-61-9

加入收藏

AKBA

货号: PC-27499Not For Human Use, Lab Use Only.

AKBA is a bioactive boswellic acid found in frankincense and allosteric, specific inhibitor of methionine adenosyltransferase 2A (MAT2A) with MST Kd of 129 nM, shows anti-inflammatory and anti-cancer properties.

规格 价格 库存 数量
10 mg ￥780 In stock
25 mg ￥1280 In stock
50 mg ￥1980 In stock
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AKBA is a bioactive boswellic acid found in frankincense and allosteric, specific inhibitor of methionine adenosyltransferase 2A (MAT2A) with MST Kd of 129 nM, shows anti-inflammatory and anti-cancer properties.
AKBA does not interact with MAT2B directly.
AKBA decreases level of S-adenosylmethionine (SAM) and SAM/SAH ratio, and reprogrammed one‑carbon metabolism in HaCaT cells.
AKBA inhibits proliferation of HaCaT cells with IC50 of 27.3 uM.
AKBA alleviates both CD18hypo and imiquimod-induced mouse models of psoriasis when applied systemically or topically.
AKBA inhibits the enzyme activity of methionine adenosine transferase 2A (MAT2A) and reprograms one-carbon metabolism in keratinocytes, which accounts for its repression of keratinocyte hyperproliferation.
AKBA moderately inhibits T helper 17 (Th17) cell differentiation.

物理化学性质&存储条件

分子量 512.73
分子式 C32H48O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bS)-3-Acetoxy-4,6a,6b,8a,11,12,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4-carboxylic acid

参考文献

1. Jing Bai, et al. EBioMedicine. 2019 Jan:39:575-590.

2. Fangzhou Lou, et al. Br J Pharmacol. 2024 Apr;181(8):1290-1307.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: