AK177

Chemical Structure : AK177

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货号: PC-26592Not For Human Use, Lab Use Only.

AK177 is a small-molecule activator of the IRE1α RNase activity with EC50 of 0.48 uM and 0.18 uM for unphosphorylated and phosphorylated IRE1α, respectively, in FRET assay.

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生物&药学活性

AK177 is a small-molecule activator of the IRE1α RNase activity with EC50 of 0.48 uM and 0.18 uM for unphosphorylated and phosphorylated IRE1α, respectively, in FRET assay.
AK177 stabilized both the phosphorylated and nonphosphorylated IRE1α upon binding measured by DSF assay in a concentration-dependent manner.

物理化学性质&存储条件

分子量	564.62
分子式	C26H28N8O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(6-((5-methyl-1H-pyrazol-3-yl)amino)-2-(4-sulfamoylphenoxy)pyrimidin-4-yl)piperazin-1-yl)-2-phenylacetic acid

参考文献

1. Avathan Veettil AK, et al. ACS Bio Med Chem Au. 2026 Feb 27;6(2):118-129.

AK177

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物理化学性质&存储条件

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AK177

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物理化学性质&存储条件

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