AK-778-XXMU

Chemical Structure : AK-778-XXMU

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货号: PC-23308Not For Human Use, Lab Use Only.

AK-778-XXMU is a small molecule inhibitor of protein ID2 (inhibitor of DNA binding 2) with SPR KD value of 129 nM.

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生物&药学活性

AK-778-XXMU is a small molecule inhibitor of protein ID2 (inhibitor of DNA binding 2) with SPR KD value of 129 nM.
AK-778-XXMU inhibits cell migration and invasion of glioma cell lines, induces apoptosis, and more importantly, slows down the tumor growth.
Serving as an inhibitor of differentiation, protein ID2 (inhibitor of DNA binding 2) plays an important role in neurogenesis, neovascularization and malignant development of gliomas.

物理化学性质&存储条件

分子量	392.84
分子式	C22H17ClN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[(3-Chlorophenyl)methyl]-1,3-dihydro-3-hydroxy-3-[2-oxo-2-(2-pyridinyl)ethyl]-2H-indol-2-one

参考文献

1. Zhong G, et al. Bioorg Med Chem. 2021 Nov 1;49:116427.

AK-778-XXMU

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AK-778-XXMU

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