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首页-小分子抑制剂&激动剂-Others-Other Targets-AJ2-30
AJ2-30

Chemical Structure : AJ2-30

CAS No.: 2700322-79-6

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AJ2-30 (SLC15A4 inhibitor AJ2-30)

货号: PC-21683Not For Human Use, Lab Use Only.

AJ2-30 is a specific small molecule SLC15A4 inhibitor with IFN-α suppression IC50 of 1.8  µM and MDP transport inhibition IC50 of 2.6  µM.

规格 价格 库存 数量
5 mg ￥1280 In stock
10 mg ￥2180 In stock
25 mg ￥3880 In stock
50 mg ￥6880 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AJ2-30 is a specific small molecule SLC15A4 inhibitor with IFN-α suppression IC50 of 1.8  µM and MDP transport inhibition IC50 of 2.6  µM.
AJ2-30 shows no activity against a related family member, SLC15A3.
AJ2-30 displays similar activity against murine Slc15a4-mediated NOD2 activation.
AJ2-30 also blocks R848-induced activation of TLR7/8 signaling as well as TriDAP-induced and MDP-induced activation of NOD1 and NOD2 signaling, respectively, in THP-1 reporter cells.
AJ2-30 (10 uM) inhibites TLR7/8-induced production of TNF-α in human monocytes, also suppresses MDP-mediated and TriDAP-mediated TNF-α production in human macrophages, displays cross-species reactivity, suppressing IFN-α production in mouse pDCs.
AJ2-30 suppresses TLR7-9 and NOD activation of mouse immune cells in an Slc15a4-dependent manner.
AJ2-30 induces lysosomal-mediated degradation of SLC15A4.
AJ2-30 reduces inflammation in lupus patient cells and mice, suppresses inflammatory cytokine production in lupus patient-derived PBMCs.

物理化学性质&存储条件

分子量 354.46
分子式 C23H22N4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((9-ethyl-9H-carbazol-3-yl)methyl)-1-methyl-1H-benzo[d]imidazol-2-amine

参考文献

1. Tzu-Yuan Chiu, et al. Nat Chem Biol. 2024 Jan 8. doi: 10.1038/s41589-023-01527-8.

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