AIMP2-DX2 inhibitor 1 | AIMP2-DX2 inhibitor | Probechem Biochemicals

Chemical Structure : AIMP2-DX2 inhibitor 1

加入收藏

AIMP2-DX2 inhibitor 1 (Compound 1)

货号: PC-72704Not For Human Use, Lab Use Only.

AIMP2-DX2 inhibitor 1 (Compound 1) is a specific chemical probe that can inhibit the tumor-promoting interaction between AIMP2-DX2 and HSP70 (IC50=2.9 uM).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

AIMP2-DX2 inhibitor 1 (Compound 1) is a specific chemical probe that can inhibit the tumor-promoting interaction between AIMP2-DX2 and HSP70 (IC50=2.9 uM).
Compound 1 showed no inhibition of PRKACA and PRKAR2A PPI at 100 uM.
Compound 1 suppressed DX2-dependent cell proliferation in a DX2-inducible system.
Compound 1 caused degradation of DX2 via inhibition of binding with HSP70.
Compound 1 inhibited of proliferation cells with the highest levels of DX2, H460 and H358 with IC50 of 0.97 and 1.29 uM, respectively, with no effect on cells with lowest level of DX2.
Compound 1 (5 and 10 mg/kg, i.p.) significantly reduced tumor size in a dose-dependent manner in vivo via a xenograft model using H460 cells, with little effect on body weight.

物理化学性质&存储条件

分子量	280.323
分子式	C18H16O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl (Z)-2-benzoyl-3-phenylacrylate

参考文献

1. Dae Gyu Kim, et al. J Pharmacol Exp Ther. 2021 Dec;379(3):358-371.

AIMP2-DX2 inhibitor 1 (Compound 1)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

AIMP2-DX2 inhibitor 1 (Compound 1)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.