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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-iGluR-AICP
AICP

Chemical Structure : AICP

CAS No.: 861213-66-3

AICP (GluN2C agonist AICP)

货号: PC-60783Not For Human Use, Lab Use Only.

AICP is a potent, selective GluN2C-selective NMDA receptor glycine site superagonist with EC50 of 1.7 nM at GluN1/2C.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AICP is a potent, selective GluN2C-selective NMDA receptor glycine site superagonist with EC50 of 1.7 nM at GluN1/2C.
    AICP is a full agonist at GluN1/2A (100% response compared with glycine), a partial agonist at GluN1/2B and GluN1/2D (10% and 27%, respectively), and a highly efficacious superagonist at GluN1/2C receptors (353%).
    AICP selectively enhances responses from recombinant GluN1/2C receptors in the presence of physiological glycine concentrations.

    物理化学性质&存储条件

    分子量 351.406
    分子式 C20H21N3O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (R)-2-amino-3-(4-(2-ethylphenyl)-1H-indole-2-carboxamido)propanoic acid

    参考文献

    1. Jessen M, et al. Mol Pharmacol. 2017 Aug;92(2):151-161.

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